Oral Macromolecule Delivery

Today, most macromolecules are delivered in traditional invasive injectable formats, which often results in poor patient compliance and are therefore not the most suitable route for long-term treatment. Although oral delivery remains the preferred route for developers of new therapies, it poses a variety of development challenges to formulation scientists, for example:

• Poor absorption due to rigid molecular geometry and flexibility
• Permeation limitations caused by tight cell junctions and limited transcellular pathways
• Low stability, because of proteolytic enzymes of the stomach and lumen, as well as harsh acidic gastric conditions

Catalent OptiGel® Bio technology incorporates a proprietary technology that may overcome the traditional hurdles by enhancing permeability and enabling a targeted delivery through enteric coating.

Our industry leading Zydis® ODT technology enables fast dissolve formulations of large molecule allergens, viral vaccines, and peptides via sub-lingual delivery.