OptiForm Pro
EXPLORE THE RANGE OF DELIVERY OPTIONS TO YOUR MOLECULE
This tool has been designed to help formulation scientists explore available options based on their small molecule target indication and specific product requirements.
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Take 8 minutes to enter what you know about your molecule's key dimensions to see its Developability Classification and potential formulation options.
TELL US WHAT YOU KNOW ABOUT YOUR MOLECULE
Selecting the right formulation technology to quickly and effectively solve bioavailability, stability and scability challenges is a vital task early in the oral drug development process.
OUR PATENT-PENDING OPTIFORM® PRO TOOL PROCESSES THAT INFORMATION ACROSS 24 DIMENSIONS
YOU'LL RECEIVE SOLUTIONS ACROSS A NUMBER OF TECHNOLOGIES
Results are based on our experience and learnings from thousands of molecules Catalent experts have worked on.
OptiForm Pro
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DEVELOPABILITY CLASSIFICATION
The DCS model is an application of biopharmaceutics concepts specifically designed for formulation development. knowledge of formulation strategies for similar compounds in the same DCS-space to your candidate allows for insight into the optimum formulation approach. Please input your Predicted Permeability in Humans, your Solubility in FAaSSIF or Water & the Target Dose. If you have not yet calculated these values, you may be able to by using many online prediction tools.
If you would like to skip the question, please click the "next" button below
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PEFF VALUE (PREDICTED PERMEABILITY IN HUMANS)
(cm/s 10^-4)
Invalid peff value (0.1 - 30)SOLUBILITY IN FASSIF (OR LESS OPTIMALLY, WATER)
(mg/mL)
Invalid S (0 – 1,000,000)UPPER DOSE IN DOSE ESCALATION (IN MG)
(mg)
Invalid target dose (0 - 100,000)
OptiForm Pro
10%
COMPLETE
PRODUCT REQUIREMENTS
Determining your target product profile will assist us in developing a tailored solution for your molecule’s challenges. Select the characteristics you are targeting for your product as they each relate to its therapeutic window, proposed patient population and type.
*All fields required.
CHEWABLE
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Yes
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No
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Don't know
VAGINAL
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Yes
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No
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Don't know
FAST ONSET OF ACTION
(Faster than 45min dissolution time)
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Yes
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No
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Don't know
CONTROLLED RELEASE
(or lower CMAX)
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Yes
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No
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Don't know
DELAYED RELEASE
(>60 minute dissolution time)
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Yes
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No
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Don't know
COMBINATION PRODUCT
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Yes
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No
-
Don't know
PEDIATRIC/GERIATRIC PATIENT POPULATION
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Yes
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No
-
Don't know
OptiForm Pro
35%
COMPLETE
ABOUT YOUR MOLECULE
90% of NCEs in today’s development pipeline suffer from poor aqueous solubility, poor permeability, or both. Select the solubility and permeability properties for your molecule.
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PARTITION COEFFICIENT
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LogP less than 1
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LogP Between 1-4
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LogP Greater than 4
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Don't know
IS YOUR COMPOUND A MACROMOLECULE?
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Yes
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No
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Don't know
OptiForm Pro
50%
COMPLETE
PHYSIOCHEMICAL PROPERTIES
Physiochemical properties of your molecule have an effect on the formulation challenges associated with delivering the molecule in the optimal dosage form to the site of action. Select the physical characteristics of your molecule.
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MELTING POINT
The temperature at which it changes state from solid to liquid at atmospheric pressure.
The temperature at which it changes state from solid to liquid at atmospheric pressure.-
Greater than 70°C
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Less than 70°C
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Don't know
PHYSICAL STATE AT ROOM TEMP
Distinct form of matter that your API takes on when at room temperature.
Distinct form of matter that your API takes on when at room temperature.-
Amorphous
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Crystalline
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Liquid Phase
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Don't know
MOLECULAR STABILITY ISSUES
Certain physical and chemical conditions can lead to the formation of impurities and degradation products. Select which of the following conditions your molecule and/or formulation is sensitive to.
Certain physical and chemical conditions can lead to the formation of impurities and degradation products. Select which of the following conditions your molecule and/or formulation is sensitive to.-
Hydrolysis
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Heat (50°C - 80°C)
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Oxydation
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Acid
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Enzymatic Degradation of the Intestines
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None of the above
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Don't know
DOES YOUR COMPOUND HAVE OR IS LIKELY TO DEGRADE TO ALDEHYDE FUNCTIONAL GROUPS?
Aldehydes are highly reactive and participate in many reactions.
Aldehydes are highly reactive and participate in many reactions.-
Yes
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No
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Don't know
OptiForm Pro
65%
COMPLETE
POTENT HANDLING AND DOSAGE
Target dosage and processing characteristics of your molecule have an affect on the manufacturing challenges and solutions available in order to deliver the drug in the optimal dosage form. Select the corresponding characteristics of your molecule.
*All fields required.
IS YOUR COMPOUND A HORMONE OR CYTOTOXIC?
Historically, regulatory authorities have assigned certain APIs to various “categories of concern”, based on their toxicological properties, in the interest of protecting patients from exposure to potentially hazardous contaminants.
Historically, regulatory authorities have assigned certain APIs to various “categories of concern”, based on their toxicological properties, in the interest of protecting patients from exposure to potentially hazardous contaminants.-
Yes
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No
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Don't know
POTENCY CLASSIFICATION
(Occupational exposure limit (OEL)ug/m3)
Molecules are becoming increasingly more and more selective in their interaction with biological targets, with pharmacological activity often being achieved with minute amounts of drug. The manufacture of highly potent drug substances and their drug products requires particular care and attention in ensuring the safety for those involved in the handling of the materials. Select if your molecule is pharmacologically active in these dose ranges.
Molecules are becoming increasingly more and more selective in their interaction with biological targets, with pharmacological activity often being achieved with minute amounts of drug. The manufacture of highly potent drug substances and their drug products requires particular care and attention in ensuring the safety for those involved in the handling of the materials. Select if your molecule is pharmacologically active in these dose ranges.-
Category 1
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Category 2
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Category 3
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Category 4
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Dont't know
AMOUNT PER UNIT
(Select two: Highest and Lowest)
Please select the therapeutic dose range you are targeting with this molecule.
Please select the therapeutic dose range you are targeting with this molecule.-
Less than 1mg
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1 - 4 mg
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5 - 200mg
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200 - 500mg
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Greater than 500mg
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Don't know
POOR FLOW (Carr's index>18)
Physical characteristics of particles, like size, shape, angularity, surface texture and porosity will all affect flow characteristics. Select if your molecule has poor particle flow properties.
Physical characteristics of particles, like size, shape, angularity, surface texture and porosity will all affect flow characteristics. Select if your molecule has poor particle flow properties.-
Yes
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No
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Don't know
OptiForm Pro
100%
COMPLETE
SUBMIT INFORMATION FOR ANALYSIS
Register now and we will provide you with your results on potential finished dose solutions specific to your molecule
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